Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A glutamatergic network mediates lithium response in bipolar disorder as defined by epigenome pathway analysis.

Pharmacogenomics - 1 Jan 2015

Higgins Gerald A, Allyn-Feuer Ari, Barbour Edward, Athey Brian D

Abstract excerpt

AIM: A regulatory network in the human brain mediating lithium response in bipolar patients was revealed by analysis of functional SNPs from genome-wide association studies (GWAS) and published gene association studies, followed by epigenome mapping. METHODS: An initial set of 23,312 SNPs in linkage disequilibrium with lead SNPs, and sub-threshold GWAS SNPs rescued by pathway analysis, were studied in the same...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antimanic Agents
Share to Bipolar Disorder
Share to Chromosome Mapping

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Computer Simulation

Share to Epigenesis, Genetic

Share to Glutamic Acid

Share to In Situ Hybridization

Share to Receptors, AMPA

Source

Identifiers

PMID: 26343379
DOI: 10.2217/pgs.15.106

Genes

ANK3
CACNG2
GRIA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A glutamatergic network mediates lithium response in bipolar disorder as defined by epigenome pathway analysis.PMID 26343379Read ↗

Exploring lithium’s transcriptional mechanisms of action in bipolar disorder: a multi-step studySemantic proximity Read ↗

Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology.Semantic proximity Read ↗

Pharmacogenomics of Lithium Response in Bipolar DisorderSemantic proximity Read ↗

Lithium partially rescues gene expression and enhancer activity from heterozygous knockout of <i>AKAP11</i> while inducing novel differential changesSemantic proximity Read ↗

A genomewide association study of response to lithium for prevention of recurrence in bipolar disorder.Semantic proximity Read ↗

An Integrative Computational Approach to Evaluate Genetic Markers for Bipolar Disorder.Semantic proximity Read ↗

Novel integrative genomic tool for interrogating lithium response in bipolar disorderSemantic proximity Read ↗

Lithium response in bipolar disorder: Epigenome-wide DNA methylation signatures and epigenetic agingSemantic proximity Read ↗

Genetic and Epigenetic Markers of Lithium ResponseSemantic proximity Read ↗

Genome-wide association study identifies 30 Loci Associated with Bipolar DisorderSemantic proximity Read ↗

Convergent functional genomics of genome‐wide association data for bipolar disorder: Comprehensive identification of candidate genes, pathways and mechanismsSemantic proximity Read ↗

Genetic variants associated with response to lithium treatment in bipolar disorder: a genome-wide association study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.