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Article

Molecular neurobiological clues to the pathogenesis of bipolar disorder.

Current opinion in neurobiology - 1 Feb 2016

Harrison Paul J

Abstract excerpt

Bipolar disorder is a serious psychiatric disorder, with a high heritability and unknown pathogenesis. Recent genome-wide association studies have identified the first loci, implicating genes such as CACNA1C and ANK3. The genes highlight several pathways, notably calcium signalling, as being of importance. Molecular studies suggest that the risk variants impact on gene regulation and expression. Preliminary...

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Identifiers

PMID: 26210959
DOI: 10.1016/j.conb.2015.07.002
PMCID: PMC4779149

Genes

ANK3

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