Back to search

Article

Abnormal Lipid Metabolism and Altered Neuronal Support by Astrocytes Lacking <i>Akap11</i> , a Risk Gene for Schizophrenia and Bipolar Disorder

2025-04-25

Abstract excerpt

A-Kinase Anchoring Protein 11 ( AKAP11 ) is a shared genetic risk factor for schizophrenia and bipolar disorder, yet its role in the brain remains poorly understood. Through multi-omic analysis of Akap11 mutant mouse brains and cultured astrocytes, we identified significant transcriptomic, proteomic, and metabolomic alterations. Key findings include the upregulation of cholesterol and fatty acid metabolic pathwa...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
d28408cb-824f-5dda-ba32-b367002a14bf
DOI
10.1101/2025.04.25.650548
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Abnormal Lipid Metabolism and Altered Neuronal Support by Astrocytes Lacking <i>Akap11</i> , a Risk Gene for Schizophrenia and Bipolar DisorderDOI 10.1101/2025.04.25.650548
Bipolar and schizophrenia risk gene <i>AKAP11</i> encodes an autophagy receptor coupling the regulation of PKA kinase network homeostasis to synaptic transmissionSemantic proximity
Bipolar and schizophrenia risk gene AKAP11 encodes an autophagy receptor coupling the regulation of PKA kinase network homeostasis to synaptic transmissionSemantic proximity
Transcriptomic and epigenomic consequences of heterozygous loss of function mutations in <i>AKAP11</i> , the first large-effect shared risk gene for bipolar disorder and schizophreniaSemantic proximity
Multi-omics reveals changes in astrocyte fatty acid metabolism during early stages of Alzheimer's diseaseSemantic proximity
<i>APOE</i> genotypes differentially remodel the astrocytic lipid droplet-associated proteome to shape lipid droplet dynamicsSemantic proximity
iPSC-derived astrocytes to model phenotype-specific differential neuroinflammatory and metabolic responses in X-linked adrenoleukodystrophySemantic proximity
Deep proteomics identifies shared molecular pathway alterations in synapses of schizophrenia and bipolar disorder patients and mouse modelSemantic proximity
Lithium partially rescues gene expression and enhancer activity from heterozygous knockout of <i>AKAP11</i> while inducing novel differential changesSemantic proximity
Acsl4-mediated Lipid Homeostasis Orchestrates Synaptic and Cognitive PlasticitySemantic proximity
Autophagy-related gene model as a novel risk factor for schizophreniaSemantic proximity
CPT2-Linked Fatty Acid Oxidation and Autophagy Nodes Connect NMN-Responsive Transcriptional Programs to Schizophrenia BiologySemantic proximity
Zebrafish screen of schizophrenia risk genes reveals convergent dysregulation of cholesterol metabolismSemantic proximity
Select a neighboring publication to make it the new centre.