Article

Molecular signatures of hyperexcitability and lithium responsiveness in bipolar disorder patient neurons provide alternative therapeutic strategies

2023-07-25

Abstract excerpt

<h4>ABSTRACT</h4> Bipolar disorder (BD) is a multifactorial psychiatric illness affecting about 1% of the world population. The first line treatment, lithium (Li), is effective in only a subset of patients and its mechanism of action remains largely elusive. In the present study, we used iPSC-derived neurons from BD patients responsive (LR) or not (LNR) to lithium and combined electrophysiology, calcium imaging,...

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Literature Corpus work: 01a9e840-4d13-528f-8bf9-8eb127669cb7
DOI: 10.1101/2023.07.21.550088

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