Article

Exome sequencing in bipolar disorder reveals shared risk gene<i>AKAP11</i>with schizophrenia

2021-03-12

Abstract excerpt

Here we report results from the Bipolar Exome (BipEx) collaboration analysis of whole exome sequencing of 13,933 individuals diagnosed with bipolar disorder (BD), matched with 14,422 controls. We find an excess of ultra-rare protein-truncating variants (PTVs) in BD patients among genes under strong evolutionary constraint, a signal evident in both major BD subtypes, bipolar 1 disorder (BD1) and bipolar 2 disorder...

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Literature Corpus work: cb9ab9c8-4028-5687-a5a8-527e4ec24ea2
DOI: 10.1101/2021.03.09.21252930

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