Article
KCNE1 enhances phosphatidylinositol 4,5-bisphosphate (PIP2) sensitivity of IKs to modulate channel activity.
Proceedings of the National Academy of Sciences of the United States of America - 31 May 2011
Li Yang, Zaydman Mark A, Wu Dick, Shi Jingyi, Guan Michael, Virgin-Downey Brett, Cui Jianmin
Abstract excerpt
Phosphatidylinositol 4,5-bisphosphate (PIP(2)) is necessary for the function of various ion channels. The potassium channel, I(Ks), is important for cardiac repolarization and requires PIP(2) to activate. Here we show that the auxiliary subunit of I(Ks), KCNE1, increases PIP(2) sensitivity 100-fold over channels formed by the pore-forming KCNQ1 subunits alone, which effectively amplifies current because native...
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