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Article

A novel human R25C-phospholamban mutation is associated with super-inhibition of calcium cycling and ventricular arrhythmia.

Cardiovascular research - 1 Jul 2015

Liu Guan-Sheng, Morales Ana, Vafiadaki Elizabeth, Lam Chi Keung, Cai Wen-Feng, Haghighi Kobra, Adly George, Hershberger Ray E, Kranias Evangelia G

Abstract excerpt

AIMS: Depressed sarcoplasmic reticulum (SR) Ca(2+) cycling, a universal characteristic of human and experimental heart failure, may be associated with genetic alterations in key Ca(2+)-handling proteins. In this study, we identified a novel PLN mutation (R25C) in dilated cardiomyopathy (DCM) and investigated its functional significance in cardiomyocyte Ca(2+)-handling and contractility. METHODS AND RESULTS: Exome...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25852082
DOI: 10.1093/cvr/cvv127
PMCID: PMC4490203

Genes

PLN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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