Article
Calcium-mediated dual-mode regulation of cardiac sodium channel gating.
Circulation research - 10 Apr 2009
Biswas Subrata, DiSilvestre Deborah, Tian Yanli, Halperin Victoria L, Tomaselli Gordon F
Abstract excerpt
Intracellular Ca(2+) ([Ca(2+)](i)) can trigger dual-mode regulation of the voltage gated cardiac sodium channel (Na(V)1.5). The channel components of the Ca(2+) regulatory system are the calmodulin (CaM)-binding IQ motif and the Ca(2+) sensing EF hand-like (EFL) motif in the carboxyl terminus of the channel. Mutations in either motif have been associated with arrhythmogenic changes in expressed Na(V)1.5 currents....
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