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Article

Cardiac potassium inward rectifier Kir2: Review of structure, regulation, pharmacology, and arrhythmogenesis.

Heart rhythm - 1 Aug 2021

Reilly Louise, Eckhardt Lee L

Abstract excerpt

Potassium inward rectifier channel Kir2 is an important component of terminal cardiac repolarization and resting membrane stability. This functionality is part of balanced cardiac excitability and is a defining feature of excitable cardiac membranes. "Gain-of-function" or "loss-of-function" mutations in KCNJ2, the gene encoding Kir2.1, cause genetic sudden cardiac death syndromes, and loss of the Kir2 current IK1...

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Identifiers

PMID: 33857643
DOI: 10.1016/j.hrthm.2021.04.008
PMCID: PMC8328935

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