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Article

Ca2+/calmodulin-dependent protein kinase II-based regulation of voltage-gated Na+ channel in cardiac disease.

Circulation - 23 Oct 2012

Koval Olha M, Snyder Jedidiah S, Wolf Roseanne M, Pavlovicz Ryan E, Glynn Patric, Curran Jerry, Leymaster Nicholas D, Dun Wen, Wright Patrick J, Cardona Natalia, Qian Lan, Mitchell Colleen C, Boyden Penelope A, Binkley Philip F, Li Chenglong, Anderson Mark E, Mohler Peter J, Hund Thomas J

Abstract excerpt

BACKGROUND: Human gene variants affecting ion channel biophysical activity and/or membrane localization are linked to potentially fatal cardiac arrhythmias. However, the mechanism for many human arrhythmia variants remains undefined despite more than a decade of investigation. Posttranslational modulation of membrane proteins is essential for normal cardiac function. Importantly, aberrant myocyte signaling has...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23008441
DOI: 10.1161/CIRCULATIONAHA.112.105320
PMCID: PMC3811023

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