Multi-Layered Genomic and Clinical Analysis Identifies Novel Variants, Co-Occurring Single Nucleotide Polymorphism Pairs, and Clinical Determinants of Host-Pathogen Interaction in COVID-19 Severity.

Abstract excerpt

Host genetic factors may contribute to COVID-19 severity. To identify genetic variants influencing COVID-19 severity progression, whole-exome sequencing was performed, followed by an exome-wide association study on 191 hospitalized patients categorized into three severity groups. The analysis identified nine loci surpassing the suggestive significance threshold (p ≤ 3 × 10-4): rs2180196 (β = 2.09, TGM1-RABGGTA),...

Topics

• Humans
• Polymorphism, Single Nucleotide
• Male
• COVID-19
• Female
• Middle Aged
• Severity of Illness Index