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Article

Integrating single-cell sequencing data with GWAS summary statistics reveals CD16+monocytes and memory CD8+T cells involved in severe COVID-19.

Genome medicine - 17 Feb 2022

Ma Yunlong, Qiu Fei, Deng Chunyu, Li Jingjing, Huang Yukuan, Wu Zeyi, Zhou Yijun, Zhang Yaru, Xiong Yichun, Yao Yinghao, Zhong Yigang, Qu Jia, Su Jianzhong

Abstract excerpt

BACKGROUND: Understanding the host genetic architecture and viral immunity contributes to the development of effective vaccines and therapeutics for controlling the COVID-19 pandemic. Alterations of immune responses in peripheral blood mononuclear cells play a crucial role in the detrimental progression of COVID-19. However, the effects of host genetic factors on immune responses for severe COVID-19 remain...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35172892
DOI: 10.1186/s13073-022-01021-1
PMCID: PMC8851814

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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