Article
Genetic contribution to severe COVID-19 in adults under 60 years without major comorbidities in the German National Pandemic Cohort Network (NAPKON).
Human genomics - 23 Jan 2026
Abolhassani Ayda, Alawathurage T Madhusankha, Schmidt Axel, Brand Fabian, Kilarski Laura L, Altmann Heidi, Dahl Edgar, Frank Sandra, Göpel Siri, Hanses Frank, Hellmuth Johannes Christian, Herr Christian, Kaasch Achim J, Kobbe Robin, Konik Margarethe Justine, Pink Isabell, Römmele Christoph, Rupp Jan, Scheer Christian S, Schneider Marc A, Stellbrink Christoph, Stubbe Hans Christian, Tepasse Phil-Robin, Teufel Andreas, Vadász István, Vehreschild Maria J G T, Witzenrath Martin, Anton Gabriele, Bröhl Isabel, Herold Susanne, Illig Thomas, Jiru-Hillmann Steffi, Krawitz Peter, Mitrov Lazar, Philipsen Alexandra, Pütz Sina M, Noethen Markus M, Nuernberg Peter, Reese Jens-Peter, Riess Olaf, Schreiber Stefan, Schultze Joachim, Steinbeis Fridolin, Vehreschild J Janne, Wildberg Christian, Ludwig Kerstin U, Schulte Eva C
Abstract excerpt
While genome-wide association studies (GWAS) have linked common genetic variants to COVID-19 susceptibility and severity, rare high-impact variants may also contribute to phenotypic heterogeneity. Inborn errors of type I interferon immunity (IFN-I-IEIs), including X-linked TLR7 deficiency, account for ~ 2% of critical COVID-19 cases. In this study, we investigated rare potentially deleterious variants in...
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