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Engineered minimal type I CRISPR-Cas system for transcriptional activation and base editing in human cells

2024-01-26

Abstract excerpt

Type I CRISPR-Cas systems are widespread and have exhibited remarkable versatility and efficiency in genome editing and gene regulation in prokaryotes. However, due to the multi-subunit composition and large size, their application in eukaryotes has not been thoroughly investigated. Here, we demonstrate that the type I-F2 Cascade, the most compact among type I systems and significantly smaller than SpCas9, can be...

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Literature Corpus work
e96d149c-0f80-5fe0-9432-0e1041963e50
DOI
10.1101/2024.01.26.577312
Open publication

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Engineered minimal type I CRISPR-Cas system for transcriptional activation and base editing in human cellsDOI 10.1101/2024.01.26.577312
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