Article

Rational design of a compact CRISPR-Cas9 activator for AAV-mediated delivery

2018-04-15

Abstract excerpt

Akin to Zinc Finger and Transcription Activator Like Effector based transcriptional modulators, nuclease-null CRISPR-Cas9 provides a groundbreaking programmable DNA binding platform, begetting an arsenal of targetable regulators for transcriptional and epigenetic perturbation, by either directly tethering, or recruiting, transcription enhancing effectors to either component of the Cas9/guide RNA complex. Applicati...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 684f709e-4d1d-5132-8e87-1245ca57a459
DOI: 10.1101/298620

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Rational design of a compact CRISPR-Cas9 activator for AAV-mediated deliveryDOI 10.1101/298620Read

The therapeutic implications of all-in-one AAV-delivered epigenome-editing platform in neurodegenerative disordersSemantic proximity Read

Genome Engineering Using Adeno-associated Virus: Basic and Clinical Research ApplicationsSemantic proximity Read

In vivo genome editing in animals using AAV-CRISPR system: applications to translational research of human diseaseSemantic proximity Read

Genome-wide activation screens to increase adeno-associated virus productionSemantic proximity Read

Genome-scale analysis of cellular restriction factors that inhibit transgene expression from adeno-associated virus vectorsSemantic proximity Read

All-in-one AAV-delivered epigenome-editing platform: <i>proof-of-concept</i> and therapeutic implications for neurodegenerative disordersSemantic proximity Read

Repurposing the TIGR-Tas system for programmable transcription activationSemantic proximity Read

Genetic and epigenetic control of gene expression by CRISPR–Cas systemsSemantic proximity Read

Optimization of S. aureus dCas9 and CRISPRi Elements for a Single Adeno-Associated Virus that Targets an Endogenous GeneSemantic proximity Read

Genome engineering using Adeno-Associated Virus (AAV).Semantic proximity Read

Viral delivery of compact CRISPR-Cas12f for <i>in vivo</i> gene editing applicationsSemantic proximity Read

A simple cloning-free method to efficiently induce gene expression using CRISPR/Cas9Semantic proximity Read