New advances in CRISPR/Cas-mediated precise gene-editing techniques.

Abstract excerpt

Over the past decade, CRISPR/Cas-based gene editing has become a powerful tool for generating mutations in a variety of model organisms, from Escherichia coli to zebrafish, rodents and large mammals. CRISPR/Cas-based gene editing effectively generates insertions or deletions (indels), which allow for rapid gene disruption. However, a large proportion of human genetic diseases are caused by single-base-pair...

Topics

• Animals
• Humans
• Gene Editing
• CRISPR-Cas Systems
• Zebrafish
• CRISPR-Associated Protein 9
• Mutation
• Mammals