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Mitochondrial impairment and repair in the pathogenesis of systemic lupus erythematosus

25 Jul 2022

Abstract excerpt

Nucleic acid autoantibodies, increase type I interferon (IFN-α) levels, and immune cell hyperactivation are hallmarks of systemic lupus erythematosus (SLE). Notably, immune cell activation requires high level of cellular energy that is predominately generated by the mitochondria. Mitochondrial reactive oxygen species (mROS), the byproduct of mitochondrial energy generation, serves as an essential mediator to...

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PMID: 35958572
DOI: 10.3389/fimmu.2022.929520

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