Article

Immune cell multi-omics analysis reveals contribution of oxidative phosphorylation to B cell functions and organ damage of lupus

2021-10-09

Abstract excerpt

<h4>Objective</h4> Systemic lupus erythematosus (SLE) is the prototypical systemic autoimmune disease, with a poor long-term prognosis. The type I interferon (IFN) signature, a prominent feature of SLE, is not an ideal therapeutic target or outcome predictor. To explore immunological pathways in SLE more precisely, we performed integrative analysis of transcriptomics, epigenomics, and genomics using each immune c...

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Literature Corpus work: 358bf083-9c2a-5016-999c-56fd5b9c5b35
DOI: 10.1101/2021.10.08.463629

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