Article

Neutrophil subsets in SLE exhibit increased glycolysis that correlates with disease activity

2026-05-18

Abstract excerpt

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterised by sustained type I interferon signalling and widespread immune dysregulation. Low-density neutrophils (LDNs) are expanded in SLE and display pro-inflammatory and tissue-damaging properties. However, their metabolic phenotype remains poorly defined. Here, we performed a comprehensive metabolic characterisation of circulating LDNs and...

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Literature Corpus work: 0cc53e03-6590-58c6-a08f-90a4181cd9d6
DOI: 10.64898/2026.05.14.725124

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