Article

Immune cell mitochondrial phenotypes are largely preserved in mitochondrial diseases and do not reflect disease severity

2025-01-22

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Objective</h4> To profile immune cell mitochondrial phenotypes in mitochondrial diseases (MitoD) and evaluate how those phenotypes relate to disease manifestations or biomarkers. <h4>Methods</h4> We profiled mitochondrial content and oxidative phosphorylation (OxPhos) enzymatic activities in isolated monocytes, lymphocytes, neutrophils, platelets, and mixed peripheral blood mononuclear cel...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7fa89f96-bd06-512c-94ca-5a6d9a9c8abd
DOI: 10.1101/2025.01.18.633635

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Immune cell mitochondrial phenotypes are largely preserved in mitochondrial diseases and do not reflect disease severityDOI 10.1101/2025.01.18.633635Read

Mitochondrial phenotypes in purified human immune cell subtypes and cell mixtures.Semantic proximity Read

Mitochondrial phenotypes in purified human immune cell subtypes and cell mixturesSemantic proximity Read

Single-cell multi-omics of mitochondrial DNA disorders reveals dynamics of purifying selection across human immune cells.Semantic proximity Read

OxPhos Dysfunction Causes Hypermetabolism and Reduces Lifespan in Cells and in Patients with Mitochondrial DiseasesSemantic proximity Read

Immune system cells from COVID-19 patients display compromised mitochondrial-nuclear expression co-regulation and rewiring toward glycolysisSemantic proximity Read

Circulating markers of NADH-reductive stress correlate with mitochondrial disease severity.Semantic proximity Read

Mitochondrial DNA aberrations and pathophysiological implications in hematopoietic diseases, chronic inflammatory diseases, and cancers.Semantic proximity Read

Genetic analysis of mitochondrial DNA copy number and associated traits identifies loci implicated in nucleotide metabolism, platelet activation, and megakaryocyte proliferation, and reveals a causal association of mitochondrial function with mortalitySemantic proximity Read

Mitochondrial genetic variation in human bioenergetics, adaptation, and adult disease.Semantic proximity Read

Mitochondrial Diagnostics: A Discovery-Based Biochemical Platform for Phenotyping Human Peripheral Blood Cell Mitochondria.Semantic proximity Read

Presentation and Diagnostic Evaluation of Mitochondrial Disease.Semantic proximity Read

Molecular insights into mitoepigenetic stress response signaling in age-associated cardiovascular disease riskSemantic proximity Read