MEGSA: A powerful and flexible framework for analyzing mutual exclusivity of tumor mutations

Abstract excerpt

The central challenge in tumor sequencing studies is to identify driver genes and pathways, investigate their functional relationships and nominate drug targets. The efficiency of these analyses, particularly for infrequently mutated genes, is compromised when patients carry different combinations of driver mutations. Mutual exclusivity analysis helps address these challenges. To identify mutually exclusive gene s...

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• Core Binding Factor Alpha 2 Subunit
• fms-Like Tyrosine Kinase 3
• GTP Phosphohydrolases
• Isocitrate Dehydrogenase
• Mediator Complex
• Nucleophosmin
• Proto-Oncogene Proteins c-kit
• Receptors, Cytoplasmic and Nuclear

Identifiers and source

Literature Corpus work

b635f039-5d44-523d-acac-dd5eb14bb3e0

DOI

10.1101/017731