Article
Detection of Combinatorial Mutational Patterns in Human Cancer Genomes by Exclusivity Analysis.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2018
Tan Hua, Zhou Xiaobo
Abstract excerpt
Cancer genes may tend to mutate in a co-mutational or mutually exclusive manner in a tumor sample of a specific cancer, which constitute two known combinatorial mutational patterns for a given gene set. Previous studies have established that genes functioning in different signaling pathways can mutate in the same sample, i.e., a tumor from one patient, while genes operating in the same pathway are rarely mutated...
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