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Article

Modeling mutual exclusivity of cancer mutations.

PLoS computational biology - 1 Mar 2014

Szczurek Ewa, Beerenwinkel Niko

Abstract excerpt

In large collections of tumor samples, it has been observed that sets of genes that are commonly involved in the same cancer pathways tend not to occur mutated together in the same patient. Such gene sets form mutually exclusive patterns of gene alterations in cancer genomic data. Computational approaches that detect mutually exclusive gene sets, rank and test candidate alteration patterns by rewarding the number...

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PMID: 24675718
DOI: 10.1371/journal.pcbi.1003503
PMCID: PMC3967923

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