Article
Using MEMo to discover mutual exclusivity modules in cancer.
Current protocols in bioinformatics - 1 Mar 2013
Ciriello Giovanni, Cerami Ethan, Aksoy Bulent Arman, Sander Chris, Schultz Nikolaus
Abstract excerpt
Although individual tumors show surprisingly diverse genomic alterations, these events tend to occur in a limited number of pathways, and alterations that affect the same pathway tend to not co-occur in the same patient. While pathway analysis has been a powerful tool in cancer genomics, our knowledge of oncogenic pathway modules is incomplete. To systematically identify such modules, we have developed a novel...
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