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Article

Identifying mutual exclusivity across cancer genomes: computational approaches to discover genetic interaction and reveal tumor vulnerability.

Briefings in bioinformatics - 18 Jan 2019

Deng Yulan, Luo Shangyi, Deng Chunyu, Luo Tao, Yin Wenkang, Zhang Hongyi, Zhang Yong, Zhang Xinxin, Lan Yujia, Ping Yanyan, Xiao Yun, Li Xia

Abstract excerpt

Systematic sequencing of cancer genomes has revealed prevalent heterogeneity, with patients harboring various combinatorial patterns of genetic alteration. In particular, a phenomenon that a group of genes exhibits mutually exclusive patterns has been widespread across cancers, covering a broad spectrum of crucial cancer pathways. Recently, there is considerable evidence showing that, mutual exclusivity reflects...

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Identifiers

PMID: 28968730
DOI: 10.1093/bib/bbx109

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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