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Article

gcMECM: graph clustering of mutual exclusivity of cancer mutations.

BMC bioinformatics - 14 Dec 2021

Hu Ying, Yan Chunhua, Chen Qingrong, Meerzaman Daoud

Abstract excerpt

BACKGROUND: Next-generation sequencing platforms allow us to sequence millions of small fragments of DNA simultaneously, revolutionizing cancer research. Sequence analysis has revealed that cancer driver genes operate across multiple intricate pathways and networks with mutations often occurring in a mutually exclusive pattern. Currently, low-frequency mutations are understudied as cancer-relevant genes,...

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PMID: 34906079
DOI: 10.1186/s12859-021-04505-w
PMCID: PMC8670134

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