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Article

A greedy approach for mutual exclusivity analysis in cancer study.

Biostatistics (Oxford, England) - 18 Jul 2022

Fang Hongyan, Zhang Zeyu, Zhou Yinsheng, Jin Lishuai, Yang Yaning

Abstract excerpt

The main challenge in cancer genomics is to distinguish the driver genes from passenger or neutral genes. Cancer genomes exhibit extensive mutational heterogeneity that no two genomes contain exactly the same somatic mutations. Such mutual exclusivity (ME) of mutations has been observed in cancer data and is associated with functional pathways. Analysis of ME patterns may provide useful clues to driver genes or...

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PMID: 33634822
DOI: 10.1093/biostatistics/kxab004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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