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Article

A weighted exact test for mutually exclusive mutations in cancer.

Bioinformatics (Oxford, England) - 1 Sept 2016

Leiserson Mark D M, Reyna Matthew A, Raphael Benjamin J

Abstract excerpt

MOTIVATION: The somatic mutations in the pathways that drive cancer development tend to be mutually exclusive across tumors, providing a signal for distinguishing driver mutations from a larger number of random passenger mutations. This mutual exclusivity signal can be confounded by high and highly variable mutation rates across a cohort of samples. Current statistical tests for exclusivity that incorporate both...

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PMID: 27587696
DOI: 10.1093/bioinformatics/btw462
PMCID: PMC5013919

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