Article

A latent variable model for evaluating mutual exclusivity and co-occurrence between driver mutations in cancer

2024-04-27

Abstract excerpt

A key challenge in cancer genomics is understanding the functional relationships and dependencies between combinations of somatic mutations that drive cancer development. Such driver mutations frequently exhibit patterns of mutual exclusivity or co-occurrence across tumors, and many methods have been developed to identify such dependency patterns from bulk DNA sequencing data of a cohort of patients. However, w...

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Literature Corpus work: dae22e00-a7bd-5a27-920c-c7d36926efa7
DOI: 10.1101/2024.04.24.590995

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