Article
MEScan: a powerful statistical framework for genome-scale mutual exclusivity analysis of cancer mutations.
Bioinformatics (Oxford, England) - 9 Jun 2021
Liu Sisheng, Liu Jinpeng, Xie Yanqi, Zhai Tingting, Hinderer Eugene W, Stromberg Arnold J, Vanderford Nathan L, Kolesar Jill M, Moseley Hunter N B, Chen Li, Liu Chunming, Wang Chi
Abstract excerpt
MOTIVATION: Cancer somatic driver mutations associated with genes within a pathway often show a mutually exclusive pattern across a cohort of patients. This mutually exclusive mutational signal has been frequently used to distinguish driver from passenger mutations and to investigate relationships among driver mutations. Current methods for de novo discovery of mutually exclusive mutational patterns are limited...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.