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Origins and consequences of centrosome aberrations in human cancers

2 Oct 2006

Abstract excerpt

Recent years have seen a revival of interest in the possible contribution of centrosomes to the development of human cancers. The underlying hypothesis, formulated almost 100 years ago (Boveri T. The origin of malignant tumors; Baltimore, MD: Williams and Wilkins, 1929.), states that numerical and/or structural centrosome abnormalities will cause chromosome [corrected] missegregation. In addition, centrosome...

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PMID: 17016823
DOI: 10.1002/ijc.22245

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