Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The caudate nucleus undergoes dramatic and unique transcriptional changes in human prodromal Huntington’s disease brain

16 Oct 2019

Abstract excerpt

BACKGROUND: The mechanisms underlying neurodegeneration in the striatum of Huntingon's Disease (HD) brain are currently unknown. While the striatum is massively degenerated in symptomatic individuals, which makes cellular characterization difficult, it is largely intact in asymptomatic HD gene positive (HD+) individuals. Unfortunately, as striatal tissue samples from HD+ individuals are exceedingly rare, recent...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyotrophic Lateral Sclerosis Research
Share to Genetic Neurodegenerative Diseases
Share to Hereditary Neurological Disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31619230
DOI: 10.1186/s12920-019-0581-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The caudate nucleus undergoes dramatic and unique transcriptional changes in human prodromal Huntington’s disease brainPMID 31619230Read ↗

The Caudate Nucleus Undergoes Dramatic and Unique Transcriptional Changes in Human Prodromal Huntington’s Disease BrainSemantic proximity Read ↗

Regional and cellular gene expression changes in human Huntington's disease brainSemantic proximity Read ↗

A common gene expression signature in Huntington’s disease patient brain regionsSemantic proximity Read ↗

Cell-specific transcription dysregulation in human Huntington’s disease-positive developing striatumSemantic proximity Read ↗

Evidence for a Pan-Neurodegenerative Disease Response in Huntington's and Parkinson's Disease Expression ProfilesSemantic proximity Read ↗

Single-nucleus RNA-seq identifies Huntington disease astrocyte statesSemantic proximity Read ↗

Comparative Huntington and Parkinson Disease mRNA Analysis Reveals Common Inflammatory ProcessesSemantic proximity Read ↗

Huntington’s disease blood and brain show a common gene expression pattern and share an immune signature with Alzheimer’s diseaseSemantic proximity Read ↗

A meta-analysis of transcriptomic profiles from Huntington’s disease patients points to a pathophysiological role of CDC42, NFY, DLX1 and PRMT3Semantic proximity Read ↗

Dissecting the molecular landscape of Parkinson’s disease and Parkinson’s disease dementia using highly efficient snRNA-seq (HIF-snRNA-seq)Semantic proximity Read ↗

Multimodal spatial transcriptomics determines repeat expansion, huntingtin aggregation, and selective cortical neuron loss in Huntington’s DiseaseSemantic proximity Read ↗

Transcriptional responses to proteotoxic stressors are profoundly diverse and tissue-specificSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.