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Concise Review: Genomic Instability in Human Stem Cells: Current Status and Future Challenges

30 Jul 2014

Abstract excerpt

Genomic instability is recognized as one of the most important hurdles in the expanding field of stem cell-based therapies. In the recent years, an accumulating body of evidence has shown that human stem cells undergo a diverse program of biological changes upon ex vivo cultivation that include numerical and structural chromosomal abnormalities, point mutations, variation of telomere length, and epigenetic...

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PMID: 25078438
DOI: 10.1002/stem.1796

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