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<i>StemCNV-check</i> : a pipeline for human pluripotent stem cell (hPSC) genomic integrity control using SNP array data and copy number variant scoring

2025-12-03

Abstract excerpt

Human pluripotent stem cells (hPSCs) and other continuously cultured cell lines are prone to acquiring mutations and genomic aberrations over time, even when derived from well-characterized cell banks. To ensure experimental reproducibility and maintain cell line integrity, routine monitoring for genomic abnormalities is essential. Single nucleotide polymorphism (SNP) arrays represent a cost-effective and widely a...

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Literature Corpus work
f2d87984-f0b6-527e-a063-79dbed1634c6
DOI
10.64898/2025.12.01.691615
Open publication

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