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Nucleosome repositioning during differentiation of a human myeloid leukemia cell line

23 Feb 2017

Abstract excerpt

Cell differentiation is associated with changes in chromatin organization and gene expression. In this study, we examine chromatin structure following differentiation of the human myeloid leukemia cell line (HL-60/S4) into granulocytes with retinoic acid (RA) or into macrophage with phorbol ester (TPA). We performed ChIP-seq of histone H3 and its modifications, analyzing changes in nucleosome occupancy,...

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Share to Acute Myeloid Leukemia Research
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PMID: 28406749
DOI: 10.1080/19491034.2017.1295201

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