Article

SALL2 constrains TEAD4 by maintaining repressive chromatin to restrict trophectoderm identity

2026-07-10

Abstract excerpt

Embryonic development is marked by the successive restriction of developmental potential and the specification of embryonic and extraembryonic lineages. Yet, how these lineage decisions are established, and how the epigenome is remodelled to promote and restrict cell fate transitions, remains poorly understood. Here, we demonstrate that SALL2 knockdown in primed human pluripotent stem cells (hPSCs) triggers a tro...

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Literature Corpus work: 5a262fca-e525-5186-ad31-aa6422cd643e
DOI: 10.64898/2026.07.10.737659

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