Article

Overexpression of CD47 is associated with brain overgrowth in 16p11.2 deletion syndrome

2019-10-17

Abstract excerpt

One of the most common genetic linkages associated with neuropsychiatric disorders, such as autism spectrum disorder and schizophrenia, occurs at the 16p11.2 locus. Copy number variants (CNVs) of the 16p gene can manifest in opposing head sizes. 16p11.2 deletion carriers tend to have macrocephaly (or brain enlargement), while those with 16p11.2 duplication frequently have microcephaly. Increases in both gray and w...

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Literature Corpus work: f31a6324-8778-5e67-b681-ec95b70f3ece
DOI: 10.1101/808022

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