Article

Sexual dimorphism of complement-dependent microglial synaptic pruning and other immune pathways in the developing brain

2017-10-17

Abstract excerpt

Sexual dimorphism has been reported in the prevalence, onset and progression of neurodevelopmental and neurodegenerative disorders. We hypothesize that immunological signaling in the developing brain, notably the complement cascade underlying microglial synaptic pruning, could be one mechanism for this dimorphism. Here we show that genes differentially expressed between male and female normal cortical development...

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Literature Corpus work: 48a1f4c8-412a-5df9-b6f4-78fb0edb05d9
DOI: 10.1101/204412

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