Article

Cascade screening following a polygenic risk score test: what is the risk of a relative conditional on a high score of a proband?

2021-04-12

Abstract excerpt

Polygenic risk scores (PRSs) for predicting disease risk have become increasingly accurate, leading to rising popularity of PRS tests. Consider an individual whose PRS test has placed him/her at the top q -quantile of genetic risk. Recently, Reid et al. (Circ Genom Precis Med. 2021;14:e003262) have investigated whether such a finding should motivate cascade screening in the proband’s siblings. Specifically, using...

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Literature Corpus work: b507ccce-a8ae-560a-af42-ed417936c3aa
DOI: 10.1101/2021.04.11.439329

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