Article

Decoding transcriptomic signatures of Cysteine String Protein alpha-mediated synapse maintenance

2023-10-03

Abstract excerpt

Synapse maintenance is essential for generating functional circuitry and decrement in this process is a hallmark of neurodegenerative disease. While we are beginning to understand the basis of synapse formation, much less is known about synapse maintenance in vivo . Cysteine string protein α (CSPα), encoded by the Dnajc5 gene, is a synaptic vesicle chaperone that is necessary for synapse maintenance and linked t...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b4f2b7c7-7e3c-54d7-8087-c9ded8b6b355
DOI: 10.1101/2023.10.02.560611

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Decoding transcriptomic signatures of Cysteine String Protein alpha-mediated synapse maintenanceDOI 10.1101/2023.10.02.560611Read

Translational profiling of neuronal subtypes in pre-symptomatic fatal familial insomnia mice reveals TOR signaling in somatostatin-expressing neuronsSemantic proximity Read

Combining comparative proteomics and molecular genetics uncovers regulators of synaptic and axonal stability and degeneration in vivo.Semantic proximity Read

S100A6 gliotransmission modulates neuronal proteostasis and energy production in the mouse and human brainSemantic proximity Read

Single-cell expression predicts neuron specific protein homeostasis networksSemantic proximity Read

Cysteine string protein-alpha prevents activity-dependent degeneration in GABAergic synapses.Semantic proximity Read

Reduced MUNC18-1 Levels, Synaptic Proteome Changes, and Altered Network Activity in STXBP1-Related Disorder Patient NeuronsSemantic proximity Read

Synapse proteomics of multiprotein complexes: en route from genes to nervous system diseases.Semantic proximity Read

Sparse Neuronal C4 Elevation Induces Network-Wide Transcriptomic and Lipid-Droplet Remodeling in the Cortical MicroenvironmentSemantic proximity Read

Astrocyte transcriptomic analysis identifies glypican 5 downregulation as a contributor to synaptic dysfunction in Alzheimer’s disease modelsSemantic proximity Read

Cysteine String Protein alpha in Extracellular Vesicle Subtypes: a Proteomic AnalysisSemantic proximity Read

PQBP1-dependent alternative RNA splicing underlies high calorie diet-induced cognitive impairmentSemantic proximity Read

Human Neuron and Mouse Models Reveal Synaptic Imbalance in Kabuki SyndromeSemantic proximity Read