Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Combining comparative proteomics and molecular genetics uncovers regulators of synaptic and axonal stability and degeneration in vivo.

PLoS genetics - 1 Jan 2012

Wishart Thomas M, Rooney Timothy M, Lamont Douglas J, Wright Ann K, Morton A Jennifer, Jackson Mandy, Freeman Marc R, Gillingwater Thomas H

Abstract excerpt

Degeneration of synaptic and axonal compartments of neurons is an early event contributing to the pathogenesis of many neurodegenerative diseases, but the underlying molecular mechanisms remain unclear. Here, we demonstrate the effectiveness of a novel "top-down" approach for identifying proteins and functional pathways regulating neurodegeneration in distal compartments of neurons. A series of comparative...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aldehyde Dehydrogenase
Share to Brain Injuries

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Calbindin 2

Share to HSP40 Heat-Shock Proteins

Share to rho-Associated Kinases

Share to S100 Calcium Binding Protein G

Share to Spinocerebellar Ataxias

Share to Thiolester Hydrolases

Source

Open in PubMed Open full text

Identifiers

PMID: 22952455
DOI: 10.1371/journal.pgen.1002936
PMCID: PMC3431337

Genes

DNAJC5
CALB2
DNAJC6
HIBCH
ROCK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Combining comparative proteomics and molecular genetics uncovers regulators of synaptic and axonal stability and degeneration in vivo.PMID 22952455Read ↗

Differential Proteomics Analysis of Synaptic Proteins Identifies Potential Cellular Targets and Protein Mediators of Synaptic Neuroprotection Conferred by the Slow Wallerian Degeneration (Wld) GeneSemantic proximity Read ↗

<i>Atxn2</i> -CAG100-KnockIn mouse spinal cord shows progressive TDP43 pathology associated with cholesterol biosynthesis suppressionSemantic proximity Read ↗

Integrative proteomics highlight presynaptic alterations and c-Jun misactivation as convergent pathomechanisms in ALSSemantic proximity Read ↗

AAV-mediated gene transfer of WDR45 corrects neurologic deficits in the mouse model of beta-propeller protein-associated neurodegenerationSemantic proximity Read ↗

Mutation in <i>Wdr45</i> leads to early motor dysfunction and widespread aberrant axon terminals in a beta-propeller protein associated neurodegeneration (BPAN) patient-inspired mouse modelSemantic proximity Read ↗

An Anatomically Resolved Mouse Brain Proteome Reveals Parkinson Disease-relevant PathwaysSemantic proximity Read ↗

Pathological characteristics of axons and proteome patterns in midbrain dopaminergic neurodegeneration induced by WDR45-deficiencySemantic proximity Read ↗

A transient protein folding response targets aggregation in the early phase of TDP-43-mediated diseaseSemantic proximity Read ↗

Decoding transcriptomic signatures of Cysteine String Protein alpha-mediated synapse maintenanceSemantic proximity Read ↗

Label-Free Quantitative Proteomic Profiling Identifies Disruption of Ubiquitin Homeostasis As a Key Driver of Schwann Cell Defects in Spinal Muscular AtrophySemantic proximity Read ↗

Functional Analysis of Late-Onset Alzheimer’s Disease Risk Genes in <i>Caenorhabditis elegans</i> Identifies Regulators of Neuronal AgingSemantic proximity Read ↗

Transcriptional Signatures of Synaptic Vesicle Genes Define Myotonic Dystrophy Type I NeurodegenerationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.