Article

PQBP1-dependent alternative RNA splicing underlies high calorie diet-induced cognitive impairment

2025-06-06

Abstract excerpt

High calorie-high fat diet (HFD) has been implicated as a pathological modifier of brain diseases including neurodegenerative dementias, but the detailed molecular mechanisms remain largely unknown. Here we report that HFD suppresses PPARγ-mediated transcriptional expression of PQBP1 , a RNA splicing factor implicated in human intellectual disability and Alzheimer’s disease. RNAseq-based comprehensive analyses of...

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Literature Corpus work: 9c51782e-9e61-5984-b0d0-a15a7a7e11f6
DOI: 10.1101/2025.06.02.657545

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