Article

Cysteine String Protein alpha in Extracellular Vesicle Subtypes: a Proteomic Analysis

2023-12-13

Abstract excerpt

Cysteine string protein (CSPα /DnaJC5) is a presynaptic J-domain protein (JDP) that prevents neurodegeneration. CSPα/DnaJC5 is reported to facilitate export of distinct, highly oligomeric, disease-causing proteins in addition to wild-type TDP-43, tau and α-synuclein. Yet, detailed mechanistic knowledge of the full CSPα/DnaJC5 secreted proteome is lacking. Understanding the CSPα/DnaJC5 export pathway has implicatio...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 025b6f7b-0f63-5625-a4e1-35f6e3d53300
DOI: 10.1101/2023.12.13.571333

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Cysteine String Protein alpha in Extracellular Vesicle Subtypes: a Proteomic AnalysisDOI 10.1101/2023.12.13.571333Read

Abnormal triaging of misfolded proteins by adult neuronal ceroid lipofuscinosis-associated DNAJC5/CSPα mutants causes lipofuscin accumulation.Semantic proximity Read

Mutations in DNAJC5, encoding cysteine-string protein alpha, cause autosomal-dominant adult-onset neuronal ceroid lipofuscinosis.Semantic proximity Read

Abnormal triaging of misfolded proteins by adult neuronal ceroid lipofuscinosis-associated CSPα mutants causes lipofuscin accumulationSemantic proximity Read

Neuronal lipofuscinosis caused by Kufs disease/CLN4 <i>DNAJC5</i> mutations but not by a CSPα/DNAJC5 deficiencySemantic proximity Read

Exome-sequencing confirms DNAJC5 mutations as cause of adult neuronal ceroid-lipofuscinosis.Semantic proximity Read

Clinically early-stage CSPα mutation carrier exhibits remarkable terminal stage neuronal pathology with minimal evidence of synaptic loss.Semantic proximity Read

Spatial proteomics reveals secretory pathway disturbances caused by neuropathy-associated TECPR2Semantic proximity Read

Decoding transcriptomic signatures of Cysteine String Protein alpha-mediated synapse maintenanceSemantic proximity Read

Proteomic analysis of extracellular vesicles in cerebrospinal fluid of patients with Alzheimer’s diseaseSemantic proximity Read

Neuronal ceroid lipofuscinosis with DNAJC5/CSPα mutation has PPT1 pathology and exhibit aberrant protein palmitoylation.Semantic proximity Read

Palmitoylation in neurodegeneration : analysis of cysteine-string protein mutants linked with neuronal ceroid lipofuscinosisSemantic proximity Read

L116 Deletion in CSPα Promotes α-Synuclein Aggregation and Neurodegeneration.Semantic proximity Read