Article

S100A6 gliotransmission modulates neuronal proteostasis and energy production in the mouse and human brain

2026-04-13

Abstract excerpt

Calcyclin binding protein (CaCyBp) is an evolutionarily conserved protein that converts S100 protein family-derived signals to protein turnover through an ubiquitin ligase interaction domain within its C-terminus. Despite its predicted roles in cellular differentiation, CaCyBp expression alone and in relation to S100A6, its prototypic ligand, during fetal and postnatal organ development remains incompletely unders...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e1cacc73-854b-512c-9791-fa3b3f1b1c8b
DOI: 10.64898/2026.04.10.717619

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

S100A6 gliotransmission modulates neuronal proteostasis and energy production in the mouse and human brainDOI 10.64898/2026.04.10.717619Read

Cell Metabolic Alterations due to Mcph1 Mutation in Microcephaly.Semantic proximity Read

Single Cell Proteomics in the Developing Human BrainSemantic proximity Read

Mutations in the transcriptional regulator MeCP2 severely impact key cellular and molecular signatures of human astrocytes during maturation.Semantic proximity Read

Temporal proteomic and PTMomic atlas of cerebral organoid developmentSemantic proximity Read

Piccolo Regulates Secretion of the Extracellular Matrix Components Brevican and Tenascin R from Astrocytes to Drive Synapse Formation: Implications for Pontocerebellar Hypoplasia Type 3 (PCH3)Semantic proximity Read

Rett Syndrome astrocytes disrupt neuronal activity and cerebral organoid development through transfer of dysfunctional mitochondriaSemantic proximity Read

Dynamic proteomic and phosphoproteomic atlas of corticostriatal axon neurodevelopmentSemantic proximity Read

Mitochondrial dysfunction and increased reactive oxygen species production in MECP2 mutant astrocytes and their impact on neurons.Semantic proximity Read

Perspectives in the investigation of Cockayne syndrome group B neurological disease: the utility of patient-derived brain organoid models.Semantic proximity Read

Decoding transcriptomic signatures of Cysteine String Protein alpha-mediated synapse maintenanceSemantic proximity Read

Cell type-specific biotin labeling <i>in vivo</i> resolves regional neuronal proteomic differences in mouse brainSemantic proximity Read

Cockayne syndrome-derived neurons display reduced synapse density and altered neural network synchrony.Semantic proximity Read