Article

<i>APOE ε4</i> allele advances the age-dependent decline of amyloid β clearance in the human cortex

2021-04-08

Abstract excerpt

<h4>Introduction</h4> Our previous study indicated that the pericapillary clearance of amyloid β (Aβ) declines with age in APOE 3/3 subjects. Here, we examine whether the APOE ε 4 allele has an impact on this age-related decline. <h4>Methods</h4> We examined 69 autopsy brains of APOE ε 3/ ε 4 or APOE ε 3/ ε 3 individuals (30-65 years) for the immunohistochemical localization of intracellular, extracell...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b4e87402-f482-54ff-be32-2926f767275b
DOI: 10.1101/2021.04.07.438832

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

<i>APOE ε4</i> allele advances the age-dependent decline of amyloid β clearance in the human cortexDOI 10.1101/2021.04.07.438832Read

Correlations between APOE4 allele and regional amyloid and tau burdens in cognitively normal older individualsSemantic proximity Read

More than just risk for Alzheimer's disease: APOE ε4's impact on the aging brain.Semantic proximity Read

APOE <i>ε</i> 4-Associated Hippocampal Atrophy Trajectories Across the Alzheimer’s Disease Continuum: A Systematic Review, Meta-Analysis, and Longitudinal ValidationSemantic proximity Read

<i>APOE</i> genotype and early β-amyloid accumulation in older adults without dementiaSemantic proximity Read

C-terminal-truncated apolipoprotein (apo) E4 inefficiently clears amyloid-β (Aβ) and acts in concert with Aβ to elicit neuronal and behavioral deficits in miceSemantic proximity Read

Soluble apoE/Aβ complex: mechanism and therapeutic target for APOE4-induced AD risk.Semantic proximity Read

Correlations between APOE4 allele and regional amyloid and tau burdens in cognitively normal older individuals.Semantic proximity Read

APOE4 is associated with greater atrophy of the hippocampal formation in Alzheimer's diseaseSemantic proximity Read

<i>APOE</i>loss-of-function variants: Compatible with longevity and associated with resistance to Alzheimer’s Disease pathologySemantic proximity Read

Reducing human apolipoprotein E levels attenuates age-dependent Aβ accumulation in mutant human amyloid precursor protein transgenic mice.Semantic proximity Read

Time Course and Severity of Cognitive Changes as a Function of Aβ Positivity and APOE Genotype in Alzheimer Disease.Semantic proximity Read

APOE4 Increases Susceptibility to Amyloid, Accelerating Episodic Memory DeclineSemantic proximity Read