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<i>APOE</i>loss-of-function variants: Compatible with longevity and associated with resistance to Alzheimer’s Disease pathology

2023-07-24

Abstract excerpt

<h4>Summary</h4> The ε4 allele of apolipoprotein E ( APOE ) is the strongest genetic risk factor for sporadic Alzheimer’s Disease (AD). Knockdown of this allele may provide a therapeutic strategy for AD, but the effect of APOE loss-of-function (LoF) on AD pathogenesis is unknown. We searched for APOE LoF variants in a large cohort of older controls and patients with AD and identified six heterozygote carriers of A...

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Literature Corpus work
f495dcce-bfea-5704-a8fb-617603b8d3dd
DOI
10.1101/2023.07.20.23292771
Open publication

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<i>APOE</i>loss-of-function variants: Compatible with longevity and associated with resistance to Alzheimer’s Disease pathologyDOI 10.1101/2023.07.20.23292771
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