Article

Keratin 17 regulates nuclear morphology and chromatin organization

2020-07-16

Abstract excerpt

Keratin 17 ( KRT17 ; K17), a non-lamin intermediate filament protein, was recently found to occur in the nucleus. We report here on K17-dependent differences in nuclear morphology, chromatin organization, and cell proliferation. Human tumor keratinocyte cell lines lacking K17 exhibit flatter nuclei relative to normal. Re-expression of wildtype K17, but not a mutant form lacking an intact nuclear localization sign...

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Literature Corpus work: b4e59bde-31d7-5f0e-bfde-c42c2a92f6f9
DOI: 10.1101/2020.07.16.206730

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