Article

Depolymerized lamins link nuclear envelope breakdown to mitotic transcriptional quiescence

2018-05-30

Abstract excerpt

<h4>ABSTRACT</h4> The nuclear envelope, a defining feature of eukaryotic cells, restricts DNA-dependent processes including gene transcription to the nucleus. The nuclear lamina is an integral component of the animal nuclear envelope, composed of polymers of nuclear lamin proteins 1,2 . Upon mitosis, the nuclear lamina disassembles, the nuclear envelope breaks down, and transcription becomes quiescent 3,4 . We...

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Literature Corpus work: 4181a69e-8712-57f6-af42-9db5221a3ad9
DOI: 10.1101/334110

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