Article
Disassembly of embryonic keratin filaments promotes pancreatic cancer metastases
2022-08-28
Abstract excerpt
Keratin 17 (K17), an oncofetal intermediate filament protein, is one of the most abundantly expressed proteins in pancreatic ductal adenocarcinomas (PDACs) of the most aggressive molecular subtype. The mechanistic roles of this protein in malignancy, however, are largely unexplored. Here we show that K17 expression and disassembly enhances tumor growth and metastatic potential and shortens survival. Using mass spe...
Topics
Open a Topic to create a Post that cites this publication.
Identifiers and source
- Literature Corpus work
- 5a165713-510c-56f2-90f4-cdaabe579758
- DOI
- 10.1101/2022.08.27.504988