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Article

Keratin 17 in disease pathogenesis: from cancer to dermatoses

10 Oct 2018

Abstract excerpt

Keratin 17 (K17) is a type I intermediate filament mainly expressed in the basal cells of epithelia. As a multifaceted cytoskeletal protein, K17 regulates a myriad of biological processes, including cell proliferation and growth, skin inflammation and hair follicle cycling. Aberrant overexpression of K17 is found in various diseases ranging from psoriasis to malignancies such as breast, cervical, oral squamous...

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PMID: 30306595
DOI: 10.1002/path.5178

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